Resveratrol was discovered as early as 1924 and was first isolated from the roots of Veratrum grandiflorum by the Japanese in 1940. In 1976, Res (resveratrol) was discovered in the leaves of grapes. It is an antitoxin secreted by plants in adversity or when encountering pathogenic damage. Its synthesis increases sharply when exposed to ultraviolet rays, mechanical damage, and fungal infection. Therefore, Called phytoantibiotics (phytoalexin). Res has been found in more than 700 species of plants, including 72 species of plants in 31 genera and 12 families, with higher levels in human foods such as grapes, knotweed and peanuts.
Physical and chemical properties
Resveratrol is a non-flavonoid polyphenol compound whose chemical name is 3,4',5-trihydroxy-1,2-diphenylethylene (3,4 ',5-Stilbenetriol), the molecular formula is C14H12O3, and the molecular weight is 228.25. The appearance of pure resveratrol is white to light yellow powder, odorless, difficult to dissolve in water, easily soluble in organic solvents such as ether, chloroform, methanol, ethanol, acetone, ethyl acetate, etc., with a melting point of 253~255°C. Sublimation temperature is 261℃. It can appear red with alkaline solutions such as ammonia water, and can react with ferric chloride-potassium ferricyanide to develop color. This property can be used to identify resveratrol.
Natural resveratrol has two structures, cis and trans. It mainly exists in trans conformation in nature. The two structures can be combined with glucose respectively to form cis and trans resveratrol glycosides. The cis- and trans-resveratrol glycosides can release resveratrol under the action of glycosidases in the intestine. Under UV light irradiation, trans-resveratrol can be converted into the cis-isomer.
Resveratrol produces fluorescence under 366nm ultraviolet light. Jeandet et al. determined the UV spectral characteristics of resveratrol and its infrared absorption peaks at 2800~3500cm (OH bond) and 965cm (trans form of double bond). Experiments have shown that trans-resveratrol is stable even if it is left for several months, except in high pH buffers, as long as it is completely isolated from light.
biological activity
Anti-aging
In 2003, Harvard University professor David Sinclair and his team discovered that resveratrol can activate acetylase and increase the life span of yeast, which triggered an upsurge in anti-aging research on resveratrol. Howitz et al. found that resveratrol can serve as the strongest activator of silent information regulation 2 homolog1 (SIRT1), can simulate the anti-aging response of calorie restriction (CR), and participate in the regulation of the average life span of organisms. . CR is a strong inducer of SIRT1 and can increase the expression of SIRT1 in organs and tissues such as the brain, heart, intestine, kidney, muscle and fat. CR can cause physiological changes that delay aging and extend lifespan, the most significant of which can be extended by 50%. Studies have confirmed that resveratrol can extend the life span of yeast, nematodes, fruit flies and lower fish.
Anti-tumor, anti-cancer
Resveratrol has significant inhibitory effects on various tumor cells such as mouse hepatocellular carcinoma, breast cancer, colon cancer, gastric cancer, and leukemia. Some scholars have confirmed that resveratrol has a significant inhibitory effect on melanoma cells through MTT method and flow cytometry.
There are reports that resveratrol can enhance cancer radiotherapy, exert a "1+1>2" effect, and effectively inhibit the effect of cancer stem cells. But so far, due to the complexity of resveratrol's anti-tumor mechanism, researchers have not yet reached a consensus on its mechanism of action.
Prevent and treat cardiovascular disease
Epidemiological studies have found that the "French paradox" phenomenon is that French people consume a large amount of fat on a daily basis, but the incidence and mortality of cardiovascular diseases are significantly lower than other European countries. This phenomenon may be related to their daily consumption of large amounts of wine. , and resveratrol may be its main active protective factor. Research shows that resveratrol can regulate blood cholesterol levels by binding to estrogen receptors in the human body, inhibit platelets from forming blood clots and adhesion to the blood vessel walls, thereby inhibiting and reducing the occurrence and development of cardiovascular disease, and reducing the risk of heart disease in the human body. Risk of vascular disease.
Other functions
Resveratrol also has antibacterial, antioxidant, immunomodulatory, antiasthmatic and other biological activities. Resveratrol is highly sought after due to its various biological activities.
Xi'an Herben Biotech Co., LTD, is a comprehensive company with many years of professional experience, integrating production, sales and service. Focusing on health care and OEM processing, it mainly exports pharmaceutical and health care raw materials, plant extracts, APIs and intermediates. The company has focused on the the research and development and production of pure shilajit resin for many years. Microorganisms reduce xylose to shilajit resin through a fermentation process. The biosynthetic method produces resin with high purity, eco-friendly, safe and high yield. We have a unique separation and purification method. Technology greatly guarantees the quality of products and supports testing by third-party professional institutions.
Please contact us for details!
Email: sales12@bpandabio.com
Tel Number/Whatsapp: +86 18066751838
Skype: 1448090890@qq.com
