what is Retatrutide?

Retatrutide is a triple hormone receptor agonist targeting GLP-1, GIP, and glucagon receptors, primarily used to treat obesity and type 2 diabetes. Here are the key information:

1.Mechanism of Action:

Delays gastric emptying and suppresses appetite by activating GLP-1 and GIP receptors;
Promotes lipoprotein and glycogenolysis by activating glucagon receptors, increasing energy expenditure.

2. Clinical Efficacy:

Weight loss: After 48 weeks of treatment, the 12 mg dose group achieved an average weight loss of 24.2%, with some patients experiencing ≥30% weight loss;
Cardiovascular benefits: Reduces triglycerides (40%) and LDL cholesterol (22%), and improves blood pressure.

3. Indications:

Obesity (BMI ≥ 30) or overweight (BMI 27-30) with metabolic diseases;
Glycemic control in patients with type 2 diabetes.

4.Research Progress The results of its Phase 2 clinical trial were published at the ADA meeting in 2023 and in the New England Journal of Medicine.

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Effects

Blood sugar control:

Retatrutide can stimulate the secretion of insulin and lower blood sugar levels, thereby effectively controlling blood sugar levels in diabetic patients.

Weight loss:

It can help people with diabetes lose weight by suppressing appetite and reducing food intake.

Cardiovascular protection:

It can reduce blood pressure and blood lipids, has a certain protective effect on cardiovascular disease, and is conducive to the prevention of cardiovascular diseases.

Liver protection:

It can reduce liver enzyme levels, protect the liver, and help prevent liver diseases.

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It is important to note that although retatrutide has a significant therapeutic effect, it is not suitable for all diabetic patients. Before using ritaglutide, patients should consult a professional doctor and take reasonable medication according to their own conditions. At the same time, patients should follow the doctor's guidance on dosage and usage during the medication process, pay attention to monitoring side effects and interactions, and consult doctors or professionals for advice in time if there are any uncomfortable symptoms or problems.

Application

Retaglutide can be used in the following areas:

Diabetes treatment:

It is a new type of hypoglycemic drug that can be used to treat type 1 and type 2 diabetes by stimulating insulin secretion and inhibiting glucagon secretion to reduce blood sugar levels.

Obesity treatment:

It can help obese patients lose weight by suppressing appetite and reducing food intake.

Prevention of cardiovascular diseases:

It can reduce blood pressure and blood lipids, has a certain protective effect on the cardiovascular system, and is conducive to the prevention of cardiovascular diseases.

Treatment of liver disease:

It can reduce the level of liver enzymes, protect the liver, and help prevent liver disease.

Other areas:

It can also be used as an adjuvant treatment for polycystic ovary syndrome, non-alcoholic fatty liver disease, Parkinson's disease, Alzheimer's disease, schizophrenia and other diseases.

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notice

The following should be noted when using itaglutide:

It is only for subcutaneous injection, not intravenous injection.

It may cause allergic skin reactions, so if you have allergic symptoms, you should stop using it immediately and consult your doctor.

It may cause gastrointestinal reactions such as nausea, vomiting, diarrhea, etc., so it is recommended to use it after a meal.

During the use of ritaglutide, blood glucose, blood pressure, body weight, liver and kidney function and other indicators should be monitored regularly in order to adjust the dosage and monitor the safety of the drug in time.

For pregnant and lactating women, it should be used with caution and, if necessary, under the guidance of a doctor.

For pediatric patients, the dosage and use method should be followed according to the doctor's guidance and should not be used arbitrarily.

If you are taking other medications while using it, you should seek the advice of your doctor or professional to avoid drug interactions.

It is a prescription drug that should be used under the guidance of a physician and should not be used by increasing or decreasing the dose or prolonging the dose.

In case of allergic reaction or serious adverse reaction, discontinue use immediately and consult a physician.

It is normal for reitaglutide to dissolve slightly in the nature of surface paste when exposed to high temperature during the validity period, so please store it in a dark and cool place.

In conclusion, when using it, you should follow your doctor's guidance on dosage and use, pay attention to monitoring side effects and interactions, and seek advice from your doctor or professional if you have any uncomfortable symptoms or problems.