AKG is the abbreviation of Alpha-Ketoglutaric Acid.
Below is its introduction from the Chemical structure, and physical properties.
From a chemical structure point of view, it is an organic compound containing a ketone group and a carboxyl group, with a molecular formula of C₅H₆O₅.
This structure gives it activity in biochemical reactions, enabling it to participate in metabolic processes in a variety of pathways.
In terms of physical properties, it is usually white crystals or crystalline powder, soluble in water, and acidic in water. This property is related to some of its functions in cells, such as regulating the pH value in cells.
AKG plays a key role in the cellular tricarboxylic acid cycle (TCA cycle), which is responsible for providing energy to cells and is involved in amino acid metabolism and protein synthesis. As we age, AKG levels decrease significantly, directly affecting cell activity, body function, and antioxidant capacity.
Supplementing exogenous AKG can effectively delay the aging process and improve a variety of age-related health problems.
Anti-aging effect
- Epigenetic regulation
AKG can regulate the modification status of histones, such as methylation and acetylation. In the nucleus of the cell, histones are like spools around which DNA is wound, and their modification status affects gene expression.
AKG delays aging to a certain extent by affecting the activity of histone demethylases and acetylases, changing the gene expression pattern, and turning on or off genes related to aging.
- Maintaining cell function
AKG can improve cell vitality and function by optimizing the metabolic environment within cells. For example, it can promote cell repair and regeneration. In skin cells, AKG may help maintain cell elasticity and vitality, reduce the formation of wrinkles, and fight aging at the cellular level.
Other effects
Maintaining stem cell self-renewal
Promote stem cell differentiation
Immunomodulatory effect
Intestinal health maintenance
