Resveratrol glycosides are widely distributed in plants and have high content. Resveratrol glycosides have been found in at least more than 70 species of plants. This time, the Vegetation Restoration and Medicinal Plant Resources Research Group of the Northwest Plateau Institute of Biology, Chinese Academy of Sciences This medicinal effect was found in Tangut rhubarb.
Tanggute rhubarb is distributed in Gansu, Qinghai and the border area between Qinghai and Tibet in China. Grows in high mountain valleys at an altitude of 1,600 to 3,000 meters.
Zhao Xiaohui, associate researcher at the Northwest Plateau Institute of Biology, Chinese Academy of Sciences, introduced that through systematic isolation and screening of chemical components in Tangut rhubarb, resveratrol glycosides have significant α-glucosidase inhibitory activity and can inhibit the meal intake of diabetic model mice. Blood sugar increases afterwards.
It is understood that diabetes is a chronic metabolic disease, mainly characterized by hyperglycemia and severe complications of diabetes, including coronary artery disease, stroke, peripheral artery disease, retinopathy, nephropathy and neuropathy.
"Adjusting postprandial blood sugar levels is an effective treatment for treating diabetes and preventing diabetes-related complications." Zhou Guoying, a researcher at Northwest Plateau Biological Research at the Chinese Academy of Sciences, said that alpha-glucosidase inhibitors have been recommended as first-line drugs for the treatment of diabetes, but this These drugs have serious side effects on the gastrointestinal tract, which limits clinical practice. Therefore, screening high-efficiency and low-toxic α-glucosidase inhibitors from natural products is a research hotspot in this field.
"In vivo study results show that oral administration of resveratrol glycosides can significantly inhibit the increase in postprandial blood sugar in normal mice and diabetic mice in a dose-dependent manner." Zhao Xiaohui said, "In addition, through enzyme kinetic analysis and molecular docking experiments , determined the competitive inhibition mechanism of resveratrol glycosides on α-glucosidase."
According to data from the International Diabetes Federation, the current prevalence of diabetes among urban residents is much higher than that among rural residents. By 2045, three-quarters of diabetic patients will live in cities. The global goal of Cities Changing Diabetes is to reduce the incidence of obesity by 25%, thereby controlling the prevalence of diabetes to less than 10% by 2045.
