Dutch scientist Anton Van Leeuwenhoek initially discovered spermidine in 1678 in a sample of human semen. Soon after, it was found in human sperm. In the human body, spermidine is made from its precursor, putrescine, and another polyamine essential for cellular function called spermine.
Polyamines can attach to numerous kinds of molecules, making them very valuable. They sustain functions, including apoptosis, cell growth, cell proliferation, and DNA stability. It also shows that polyamines function similarly to growth factors during cell division. This is why putrescine and spermidine are essential for healthy tissue growth and function.
While not a cure-all, spermidine has undeniable benefits for holistic health. With effects ranging from disease protection to hair health and applications in areas as diverse as coronavirus and fertility, regularly taking spermidine supplements can boost the health and longevity effects of a healthy lifestyle. Maintaining our spermidine levels as we age by eating foods high in spermidine or taking supplements should be a priority in protecting future longevity.
Spermidine is found in all eukaryotic cells, where it plays an integral role in cell metabolism. In some bacteria, it is an essential growth factor and it is also a polycation at physiological pH. While spermidine is available in whole foods, it can also be found in higher concentrations in food-extracted supplements – the most effective way of maintaining high spermidine intake.
Spermidine supplements have been lauded for their antiaging benefits, but how does spermidine actually work inside the body?
Common dietary supplements are designed to provide your body with nutrients missing from the modern diet and protect against deficiencies. Longevity supplements like spermidine instead contain active ingredients that work on the molecular pathways that control how we age.
As we age, we accumulate a variety of molecular and cellular damage that results in the hallmarks of aging. Longevity supplements work on the pathways that control the aging process rather than on aging itself. For example, spermidine induces autophagy, the process of cellular rejuvenation, through the TOR kinase pathway. Autophagy occurs naturally in cells as it regulates cellular metabolism. Autophagy also balances nutrients during cell stress so can be can be accelerated by fasting or by caloric restriction mimetics (CRMs) like spermidine that mimic fasting's effects on the body. During autophagy, cells reuse their old or damaged organelles to achieve cellular renewal and its anti-aging benefits. Indeed, autophagy is thought to limit inflammation and oxidative stress, the main culprits involved in aging and related diseases.
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