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Retatrutide (LY-3437943) is a developing drug for treating obesity and type 2 diabetes mellitus. This active compound activates receptor agonists in our bodies that help with blood sugar control and body weight loss management. Just like Ozempic or Wegovy (semaglutide), retatrutide is a glucagon-like peptide-1 (GLP-1) agonist. And in the same way as Mounjaro, this new drug also acts as another hormone called glucose-dependent insulinotropic polypeptide (GIP). Both hormones combined do wonders in promoting weight loss. But retatrutide takes the game one step further; this drug also acts as a third hormone: glucagon.
Benefits of Retatrutide Peptide
Significant weight reduction
Phase II trials have demonstrated substantial weight loss, with average losses of 17.5% and 24.4% at 24 and 48 weeks, respectively.
Appetite suppression
By mimicking hormones like GLP-1, retatrutide signals the brain that you are full, which reduces appetite and prevents overeating.
Improved metabolic markers
Retatrutide peptide :The medication shows significant improvements in metabolic markers in patients with overweight, obesity, and/or type 2 diabetes.
Reduced liver fat
Significant reductions in liver fat have been observed, which correlates strongly with weight loss.
Improved glycemic control
Retatrutide has been shown to improve glycemic control, which is beneficial for individuals with type 2 diabetes.
Cardiovascular benefits
Initial studies indicate potential cardiovascular benefits in addition to its effects on weight and blood sugar.
Retatrutide vs. Other Weight Loss Drugs
When it comes to Retatrutide, the novel medication acts by targeting glucagon receptors, leading to superior weight loss. Specifically, the glucagon signals the liver to exert stored sugar, soon to be broken down by the bodyDespite the ongoing research, preliminary data from the phase 2 trial indicate that Retatrutide may surpass other weight-loss drugs introduced by Eli Lilly when treating obesity and related conditions.it is evident that Retatrutide is expected to precede its predecessors by facilitating people with obesity and other overweight-related conditions, shedding extra weight by up to 25%. an endocrinologist the phase 2 trial demonstrates that Retatrutide might be more potent for regulating hunger, quoted as "the most effective anti-obesity med to date."
How Retatrutide Works
1.Astric inhibitory polypeptide receptor (GIPR) agonist
As a GIP receptor agonist, retatrutide enhances appetite suppression and prevents fat accumulation, resulting in decreased energy intake and increased energy expenditure.
2.Glucagon-like peptide 1 receptor (GLP-1R) agonist
Retatrutide reduces body weight by improving blood sugar levels via enhanced insulin release from the pancreas and reduced release of glucagon (a hormone that increases blood sugar).
3.Glucagon receptor (GR) agonist
Retatrutide decreases glucagon release to improve blood sugar levels, decrease food intake, and increase energy expenditure which ultimately results in weight loss.
Retatrutide is a new drug for obesity that is currently being developed by Eli Lilly. The initial dose of retatrutide is 0.5 mg, which is injected subcutaneously once weekly. The dose of the drug can be increased to 1 mg, 2 mg, or 4 mg after 4 weeks, depending on the patient's response. The maximum dose is 12 mg per week.
The initial dose of retatrutide is important because it helps to minimize the risk of side effects. If the patient tolerates the initial dose well, the dose can be increased gradually. However, if the patient experiences any serious side effects, the dose of the drug should be reduced or discontinued.
For peptide drugs like retatrutide, the most conservative and safest general recommendation after reconstitution is: Use immediately. If immediate use is not possible, use within 2 to 4 weeks after reconstitution under refrigerated conditions (2°C to 8°C).
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