What is fisetin 99% powder?
Fisetin is a natural product usually extracted from the bark of the sumac tree. it is a widely used natural dye in fields such as lacquerware and textiles.
In addition to being a dye, it has been shown to have many important biological activities, such as antioxidant, antibacterial, anti-inflammatory, antitumor, and immunomodulatory, etc. Therefore, it can be used in fields such as medicine, health care, food and cosmetics.
The wide application of this product is due to its natural composition and safety, and its antioxidant and anti-inflammatory effects. This makes it a natural compound worthy of research and development, providing people with more healthier choices.
In conclusion, it is a very important natural product with many beneficial biological activities. Its wide application will contribute to our life and health. Due to its naturalness and safety, it is believed that it will definitely get more attention and research in the future development.
COA
|
Identification |
Specification |
Result |
|
Appearance |
Yellow powder |
Complies |
|
Odor |
characteristic |
Complies |
|
Particle size |
100% through 80 mesh |
Complies |
|
Loss on Drying |
≤5.0% |
1.45% |
|
Melting Point |
130～142℃ |
Complies |
|
Stigmasterol |
≥15.0% |
23.6% |
|
Brassicasterol |
≤5.0% |
0.8% |
|
Campesterol |
≥20.0% |
23.1% |
|
β-sitosterol |
≥40.0% |
41.4% |
|
Other sterol |
≤3.0% |
0.71% |
|
Total Sterols Assay |
≥90% |
90.06%(GC) |
|
Pb |
≤10ppm |
Complies |
|
Microbiological Data |
||
|
Total Aerobic Count |
≤10000cfu/g |
Complies |
|
Yeast & Mold |
≤1000cfu/g |
Complies |
|
E.Coli |
Negative |
Complies |
|
Salmonella |
Negative |
Complies |
Which food contain fisetin?
fisetin 99% powder is one of its particularly well-studied flavonoids. 1 Theoretically, it is a flavonol molecule similar to those found in dark chocolate and cocoa. Traces of fisetin can also be found in certain fruits and vegetables.
isetin
Based on existing research, the highest levels of the ingredients are found in strawberries, followed by apples. Strawberries contain about five times as much fisetin as apples, and generally more than 30 times as much as mangoes, kiwis, grapes, tomatoes, Onions, cucumbers and various nuts.
However, the amount of the ingredients in these foods is still not enough to match the amount of it in dietary supplements. In Japan, the average estimated daily intake of it is 0.4 mg. As a dietary supplement, the recommended daily dose of it should be 100 mg.
What is the benefits of fisetin 99% powder
Like other flavonoid sources such as quercetin, resveratrol, and grape seed extract, fisetin also plays a myriad of beneficial roles. The focus of this article will be on the unique effects of it on brain health, cognition, and memory.
This product optimizes brain health in the following ways:
· Activates antioxidant mechanisms that protect brain cells from damage.
· Increases the glutathione content in brain cells to further protect the brain while optimizing body clarity and enhancing cell energy.
· Supports the growth of new brain cells.
· Stimulates and helps brain circuits and brain signaling pathways involved in long-term memory function.
Much of the research onfisetin's effects on brain health has been conducted at the prestigious Salk Institute for Biological Studies in San Diego, focusing on fisetin as a "puzzle substance" and a "neurotrophic factor." Nootropics are substances that enhance memory and brain function. Several other natural compounds that play this role include hericium ericium extract, PQQ with coenzyme Q10, resveratrol, and curcumin.
What makes it different is its role as a neurotrophic factor. These compounds support the survival, differentiation and functional maintenance of brain cells. In other words, what's different about it is that, in addition to helping brain cells function better, it also plays a role as a neuronutrient in optimizing what's called "brain plasticity."
Brain plasticity is the ability of the brain to respond to the development of new or restored brain circuits. Brain plasticity is important for the normal functioning of the brain such as learning and memory. Thus, by acting as a neurotrophic agent to optimize brain plasticity, it can actually produce optimization of brain circuits and brain signaling pathways related to long-term memory function.
How does fesetin works?
Fisetin can cross the blood-brain barrier through a very complex set of mechanisms to produce its effects as an educational and neurotrophic agent. While it acts a little differently than other compounds, it does operate in many of the same ways as other flavonoids. For example, it shares some anti-aging properties with resveratrol. It is an excellent anti-aging agent, which means it can help the body and brain get rid of old cells, creating a "pruning" effect, allowing healthy cells to flourish or replace old cells. In terms of this ability, it was about twice as effective as quercetin.
Like other flavonoids, fisetin also enhances the production of glutathione, a key antioxidant and body cleanser in our cells. Optimizing glutathione levels in the brain yields various benefits as the brain is better able to protect itself from damage and has higher cellular energy levels. 2. One of fisetin's key roles is to initiate the so-called ERK pathway. 3 ERK is short for "Extracellular signal-regulated kinase," which means on the periphery of the cell, and kinase refers to a class of enzymes. So ERK is when something outside the cell sends a signal to the inside of the cell to activate the kinase.
It helps brain cells produce proteins that are essential for the structure and function of brain cells, particularly at communication nodes between cells called synapses. It also reduces various inflammatory responses within synaptic connections.
By activating the ERK pathway, it can optimize brain cell structure and function. This means it can help optimize cognition and memory. This effect has been repeatedly demonstrated in preclinical studies.
How to made fisetin?
The process of making Fisetin can be divided into the following steps:
Collecting paint and yellow tree
Fisetin is extracted from the resin of sumac and yellow tree, and it is necessary to collect enough paint and yellow tree first.
Cut paint and yellow trees
The collected paint and yellow trees are cut into small pieces for better subsequent processing.
Extract resin
Put the cut paint and yellow tree blocks into the extractor and extract the resin using a solvent. The solvent can be an organic solvent, such as an alcohol, an ether, or a hydrocarbon. This step is designed to dissolve the resin from the sumac and yellow trees.
Filtration
The extracted resin solution is filtered to remove impurities and solid residues.
Concentration
The filtered resin solution is concentrated to make it more pure and concentrated.
Crystallization and separation
The concentrated resin solution is crystallized and the resin crystallizes out by controlling temperature and other conditions. The resin particles are then separated from the solution.
Drying
The separated resin particles are dried to remove moisture and other residues from them.
According to the need, the dried resin is further refined to improve the purity and quality of Fisetin.
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